Quinidine                package:nlme                R Documentation

_Q_u_i_n_i_d_i_n_e _K_i_n_e_t_i_c_s

_D_e_s_c_r_i_p_t_i_o_n:

     The 'Quinidine' data frame has 1471 rows and 14 columns.

_F_o_r_m_a_t:

     This data frame contains the following columns:

     _S_u_b_j_e_c_t a factor identifying the patient on whom the data were
          collected.

     _t_i_m_e a numeric vector giving the time (hr) at which the drug was
          administered or the blood sample drawn.  This is measured
          from the time the patient entered the study.

     _c_o_n_c a numeric vector giving the serum quinidine concentration
          (mg/L).

     _d_o_s_e a numeric vector giving the dose of drug administered (mg).
          Although there were two different forms of quinidine
          administered, the doses were adjusted for differences in salt
          content by conversion to milligrams of quinidine base.

     _i_n_t_e_r_v_a_l a numeric vector giving the when the drug has been given
          at regular intervals for a sufficiently long period of time
          to assume steady state behavior, the interval is recorded.

     _A_g_e a numeric vector giving the age of the subject on entry to the
          study (yr).

     _H_e_i_g_h_t a numeric vector giving the height of the subject on entry
          to the study (in.).

     _W_e_i_g_h_t a numeric vector giving the body weight of the subject
          (kg).

     _R_a_c_e a factor with levels 'Caucasian',  'Latin', and 'Black'
          identifying the race of the subject.

     _S_m_o_k_e a factor with levels 'no' and 'yes' giving smoking status at
          the time of the measurement.

     _E_t_h_a_n_o_l a factor with levels 'none',  'current', 'former' giving
          ethanol (alcohol) abuse status at the time of the
          measurement.

     _H_e_a_r_t a factor with levels 'No/Mild',  'Moderate', and  'Severe'
          indicating congestive heart failure for the subject.

     _C_r_e_a_t_i_n_i_n_e an ordered factor with levels '< 50' < '>= 50'
          indicating the creatine clearance (mg/min).

     _g_l_y_c_o a numeric vector giving the alpha-1 acid glycoprotein
          concentration (mg/dL).  Often measured at the same time as
          the quinidine concentration.


_D_e_t_a_i_l_s:

     Verme et al. (1992) analyze routine clinical data on patients
     receiving the drug quinidine as a treatment for cardiac arrythmia
     (atrial fibrillation of ventricular arrythmias).  All patients
     were receiving oral quinidine doses.  At irregular intervals blood
     samples were drawn and serum concentrations of quinidine were
     determined.  These data are analyzed in several publications,
     including Davidian and Giltinan (1995, section 9.3).

_S_o_u_r_c_e:

     Pinheiro, J. C. and Bates, D. M. (2000), _Mixed-Effects Models in
     S and S-PLUS_, Springer, New York.  (Appendix A.25)

     Davidian, M. and Giltinan, D. M. (1995), _Nonlinear Models for
     Repeated Measurement Data_,  Chapman and Hall, London.

     Verme, C. N., Ludden,  T. M., Clementi, W. A. and Harris, S. C.
     (1992), Pharmacokinetics of quinidine in male patients: A
     population analysis, _Clinical Pharmacokinetics_, *22*, 468-480.

